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Ibuprofen (2-4'-isobutylphenylpropionic acid) is an anti-inflammatory, analgesic, and antipyretic agent which is now frequently used in the treatment of rheumatoid and osteo- arthritis. The drug is remarkably free of side-effects and no serious toxicity has been demonstrated in extensive clinical trials, apart from one case of gastrointestinal bleeding (Dick-Smith, I969). Minor toxic effects which have been reported are listed in Table
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Collum et al. (1971) studied this question.
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