Key result
DOACs in AF are linked to normal platelet aggregates but potentially increased active platelet forms.
Why the study?
Do direct oral anticoagulants affect intravascular platelet activity in patients with paroxysmal and persistent atrial fibrillation?
Observational
Do direct oral anticoagulants affect intravascular platelet activity in patients with paroxysmal and persistent atrial fibrillation?
Patients with atrial fibrillation taking direct oral anticoagulants may exhibit a tendency toward increased active forms of platelets despite normal levels of platelet aggregates.
May suggest subtle platelet activation on DOACs in AF; hypothesis-generating and should not yet change practice.
The article presents an analysis of changes in the platelet component of the hemostatic system in patients with paroxysmal and persistent forms of atrial fibrillation while taking direct oral anticoagulants. This group of medications is used for the prevention of ischemic stroke and other systemic thromboembolic events. The number of platelets involved in aggregates was within normal limits; however, there is a tendency toward an increase in active forms of platelets in these patients.
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Bobyleva et al. (2025) conducted an observational in Atrial fibrillation. Direct oral anticoagulants was evaluated on Changes in the platelet component of the hemostatic system (intravascular platelet activity). Direct oral anticoagulants in patients with atrial fibrillation were associated with normal levels of platelets in aggregates but a tendency toward an increase in active forms of platelets.
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