Why the study?
Manifestations of metabolic syndrome carry risks for atrial fibrillation, but whether any electrocardiographic parameter can reflect increased risk was undetermined.
Are the extremes of QTc interval duration associated with an increased presence of atrial fibrillation in individuals with metabolic syndrome phenotypes?
Cross-Sectional (n=4,479)
No
Are the extremes of QTc interval duration associated with an increased presence of atrial fibrillation in individuals with metabolic syndrome phenotypes?
Odds Ratio: 1.46 (95% CI 1.13–1.89)
p-value: p=0.003
Both abnormally short and long QTc intervals on standard ECG are markers associated with an increased presence of atrial fibrillation in patients with metabolic syndrome.
QTc extremes may flag higher AF presence in metabolic syndrome; hypothesis-generating and requires prospective validation before clinical use.
Purpose: Manifestations of metabolic syndrome (MetS) carry risks for atrial fibrillation (AF). The study determined whether any electrocardiographic parameter can reflect increased AF risk in individuals with MetS. Patients and Methods: From our University Hospital database, we examined the presence of AF and its correlation with MetS manifestations, renal function, lipid profiles, and electrocardiographic parameters (P wave duration, PR interval, QRS width, and QTc intervals). Between January 2008 and December 2015, data from 4479 adults (women 41.6% vs men 58.4%) were identified. Results: The overall prevalence of AF was 12.4%, without sex differences (women, 12.8% vs men, 12.1%). Patients with AF were older (age 73.9 ± 11.8 vs non-AF 67 ± 13.5 years), with lower lipid levels (TG, total cholesterol, and LDL-cholesterol, all p < 0.0001), and at lower eGFR level (64.1 ± 30.9 vs non-AF 68.8 ± 41.4 mL/min/1.73m2, p < 0.0001). Besides, sex differences were present in all electrocardiographic parameters (all p < 0.05). Hypertension had the highest odds ratio (1.33; p = 0.026) for AF. Comparing AF to non-AF, the QTc of quartiles was significantly different (p < 0.0089). The shortest and longest QTc quartiles had an increased incidence of AF. Conclusion: AF risk in patients with MetS phenotypes can be reflected by QTc quartiles.
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Lee et al. (2022) conducted a cross-sectional in Metabolic Syndrome (MetS) manifestations (n=4,479). QTc interval duration (shortest and longest quartiles) vs. Middle QTc interval quartiles was evaluated on Presence of atrial fibrillation (OR 1.46, 95% CI 1.13-1.89, p=0.003).
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