Key result
Elevated homocysteine is ~2-fold higher in CAD vs controls but fails to predict disease extent.
Why the study?
Does hyperhomocysteinemia and MTHFR C677T polymorphism increase the risk of coronary artery disease in patients undergoing coronary angiography?
Case-Control (n=90)
No
Does hyperhomocysteinemia and MTHFR C677T polymorphism increase the risk of coronary artery disease in patients undergoing coronary angiography?
Absolute Event Rate: 22.3% vs 10.6%
p-value: p=<0.001
Elevated plasma homocysteine is significantly associated with the presence of coronary artery disease but does not predict the extent of vessel involvement.
Elevated homocysteine was associated with CAD presence but not extent; leaves open causal role and biomarker utility pending prospective studies.
BACKGROUND: Hyperhomocysteinemia has recently been identified as a risk factor for coronary artery disease. Some genetic variants (such as C677T polymorphism) are postulated in this regard. We studied the relation between hyperhomocysteinemia and the above genetic variant and risk of coronary artery disease (CAD) and also the number of involved vessels. MATERIALS AND METHODS: From a total of 90 patients, 45 showed angiographically documented CAD and 45 had clinical manifestations of CAD but a negative angiography. Blood homocysteine level and C677T polymorphism were evaluated by Enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) respectively. RESULTS: Homocysteine level was significantly higher in the case group (P < 0.001) but no correlation was found between its level and extent of CAD. More homozygote cases of C677T allele were detected in the case group which was not related to the extent of CAD either. CONCLUSION: Presence of hyperhomocysteinemia increases the risk of CAD but does not predict the extent of it.
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Shakerian et al. (2012) conducted a case-control in Coronary artery disease (n=90). Elevated plasma homocysteine and MTHFR C677T polymorphism vs. Negative coronary angiography (controls) was evaluated on Plasma homocysteine level (p=<0.001). Plasma homocysteine levels were significantly higher in patients with coronary artery disease compared to controls (22.3 vs 10.6, p<0.001), but did not predict the extent of vessel involvement.
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