Why the study?
Is the MTHFR C677T gene polymorphism and hyperhomocysteinemia associated with an increased risk of myocardial infarction in younger Indians?
Is the MTHFR C677T gene polymorphism and hyperhomocysteinemia associated with an increased risk of myocardial infarction in younger Indians?
In a very small cohort of younger Indians, the MTHFR C677T polymorphism and elevated plasma homocysteine levels were significantly associated with myocardial infarction.
Hyperhomocysteinemia may be associated with MI risk in younger Indians; hypothesis-generating and should not yet change practice.
Homocysteine is an emerging new risk factor for cardiovascular disease. A common polymorphism in the gene coding for the 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with a decreased activity of the enzyme due to thermolability. There is an accumulating evidence that adequate intake of folate may protect the risk of developing the athero-thrombotic disease and its complications. Hyperhomocysteinemia (HCA)either due to mutation of MTHFR gene or deficiency of vitamin B12 and folic acid, has been reported as a risk factor for coronary artery disease (CAD).the present study was aimed to determine plasma homocysteine (hcy) levels and to evaluate MTHFR C677T gene polymorphism as risk factors for CAD in younger Indians. the effect of vitamin B12 and folic acid supplements on the raised plasma hcy levels in patients with CAD was also assessed. In our results, 6 cases are effected with a mutation in MTHFR gene. among them 4 individuals may face the future threat of myocardial infarction remaining 2 individuals are mutated and risk factors are similar to that of myocardial infarction.
No takes yet. Share an insight, caveat, or question.
Venkatesh et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: