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Models describe packing rules for alpha-helices and pleated sheets, indicating major determinants in protein structure.
Simple models are presented that describe the rules for almost all the packing that occurs between and among alpha-helices and pleated sheets. These packing rules, together with the primary and secondary structures, are the major determinants of the three-dimensional structure of proteins.
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Chothia et al. (1977) studied this question.
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