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January 1, 2012Frontiers in NeurologyOpen Access

Cerebral Microbleeds on Magnetic Resonance Imaging and Anticoagulant-Associated Intracerebral Hemorrhage Risk

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Why the study?

Do cerebral microbleeds on MRI predict the risk of intracerebral hemorrhage in patients receiving oral anticoagulation for atrial fibrillation?

Population

Patients with atrial fibrillation treated with oral anticoagulation, particularly those with prior ischemic…

Design

Review

Key result

Cerebral microbleeds have emerged as a key MRI marker of small vessel disease and a potentially powerful predictor of future anticoagulant-associated intracerebral hemorrhage risk.

Authors

ACAndreas CharidimouCSClare ShakeshaftDWDavid J. Werring

Discussion

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Overview

May support CMB risk stratification in anticoagulated AF; leaves open need for prospective validation before clinical use.

Structured PICO

Do cerebral microbleeds on MRI predict the risk of intracerebral hemorrhage in patients receiving oral anticoagulation for atrial fibrillation?

P
Population
Patients with atrial fibrillation (AF) treated with oral anticoagulation, particularly those with prior ischemic stroke and cerebral small vessel disease.
E
Exposure
Oral anticoagulation
O
Outcome
Anticoagulant-associated intracerebral hemorrhage (ICH)safety

Cerebral microbleeds identified on MRI may serve as a key biomarker for predicting the risk of devastating intracerebral hemorrhage in patients receiving oral anticoagulation for atrial fibrillation.

Limitations

  • Lack of adequately powered, high quality prospective studies of CMBs and ICH risk on anticoagulation
  • Heterogeneity in patient characteristics across existing studies
  • Lack of standardization of imaging data or CMB rating in previous studies
  • Adequately powered, high quality prospective studies of CMBs and ICH risk on anticoagulation are not available
  • RCTs designed to evaluate the efficacy of warfarin in AF may not be the optimum design to investigate rare adverse events like ICH

Cite This Study

Charidimou et al. (2012) conducted a review in Atrial fibrillation and cerebral small vessel disease. Anticoagulants was evaluated on Intracerebral hemorrhage. Cerebral microbleeds have emerged as a key MRI marker of small vessel disease and a potentially powerful predictor of future anticoagulant-associated intracerebral hemorrhage risk.

synapsesocial.com/papers/6a230db549ad601d9cd27733https://doi.org/10.3389/fneur.2012.00133
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