Key result
The scrapie agent (prion) resisted inactivation by procedures that modify nucleic acids but was inactivated by procedures that modify proteins, distinguishing it from viroids and viruses.
Population
Scrapie agent adapted to hamsters and potato spindle tuber viroid propagated in tomato plants.
Comparison
Exposure to various chemical and physical… vs Comparison of responses between PSTV and the…
Design
Preclinical
Authors
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Animal data support protein-only prions; leaves open human applicability and targeted therapies.
The scrapie agent's resistance to nucleic acid-modifying procedures and sensitivity to protein-modifying procedures distinguishes it from viroids and supports the concept of the 'prion'.
Diener et al. (1982) studied Degenerative neurological disease (scrapie). Scrapie agent (prion) vs. Potato spindle tuber viroid (PSTV) was evaluated on Inactivation by various chemical and enzymatic procedures. The scrapie agent (prion) resisted inactivation by procedures that modify nucleic acids but was inactivated by procedures that modify proteins, distinguishing it from viroids and viruses.
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