Key result
In patients with Type 1 diabetes, age-corrected intima-media thickness significantly correlated with total cholesterol (r=0.43, p<0.01) and LDL-cholesterol (r=0.42, p<0.01), but not HDL-cholesterol.
Population
50 patients with Type 1 diabetes mellitus attending diabetic clinics at St Mary's and St Charles' Hospitals…
Design
Cross-sectional
Authors
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May support prioritizing total and LDL over HDL cholesterol in Type 1 diabetes assessment; leaves open causal links and needs prospective validation.
Cross-Sectional (n=50)
Yes
Effect estimate: r = 0.43 for total cholesterol; r = 0.42 for LDL-cholesterol
p-value: p=< 0.01
In patients with Type 1 diabetes, total and LDL-cholesterol, but not HDL-cholesterol, are correlated with the extent of atherosclerotic disease as measured by ultrasound intima-media thickness.
Merrin et al. (1994) conducted a cross-sectional in Type 1 diabetes mellitus (n=50). Serum lipids and apolipoproteins was evaluated on Intima-media thickness (r = 0.43 for total cholesterol; r = 0.42 for LDL-cholesterol, p=< 0.01). In patients with Type 1 diabetes, age-corrected intima-media thickness significantly correlated with total cholesterol (r=0.43, p<0.01) and LDL-cholesterol (r=0.42, p<0.01), but not HDL-cholesterol.
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