Why the study?
Atrial fibrillation and stroke are complex traits whose susceptibility genetic determinants and putative shared etiologic mechanisms have been investigated through genome-wide association studies.
Genetic variants associated with atrial fibrillation overlap with those for cardioembolic stroke, suggesting shared etiologic mechanisms and potential for genetic risk scores in stroke prediction.
May support genetic risk scores for AF-related stroke; leaves open prospective validation before clinical adoption.
Atrial fibrillation (AF) and stroke are included in a group of complex traits that have been approached regarding of their study by susceptibility genetic determinants. Since 2007, several genome-wide association studies (GWAS) aiming to identify genetic variants modulating AF risk have been conducted. Thus, 11 GWAS have identified 26 SNPs (p < 5 × 10-2), of which 19 reached genome-wide significance (p < 5 × 10-8). From those variants, seven were also associated with cardioembolic stroke and three reached genome-wide significance in stroke GWAS. These associations may shed a light on putative shared etiologic mechanisms between AF and cardioembolic stroke. Additionally, some of these identified variants have been incorporated in genetic risk scores in order to elucidate new approaches of stroke prediction, prevention and treatment.
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Cruz et al. (2019) conducted a review in Atrial fibrillation and stroke. Genetic variants (SNPs) was evaluated on Genetic variants modulating AF risk.
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