Key result
A multilocus genetic risk score combining 13 SNPs was significantly and independently associated with atrial fibrillation in hemodialyzed patients with end-stage kidney disease (OR 1.24 per 0.1-unit increase).
Why the study?
Does a multilocus genetic risk score (GRS) associate with atrial fibrillation in haemodialysed patients with end-stage kidney disease?
Case-Control (n=270)
Yes
Does a multilocus genetic risk score (GRS) associate with atrial fibrillation in haemodialysed patients with end-stage kidney disease?
A 13-SNP genetic risk score is independently associated with atrial fibrillation in haemodialysed patients with end-stage kidney disease, highlighting a genetic predisposition to AF in this high-risk population.
Supports genetic AF predisposition in end-stage kidney disease on dialysis; leaves open GRS utility for risk stratification.
Genetic factors play a key role in the pathogenesis of atrial fibrillation (AF). We would like to establish an association between previously described single-nucleotide polymorphisms (SNPs) and AF in haemodialysed patients with end-stage kidney disease (ESKD-HD) as well as to assess the cumulative effect of all genotyped SNPs on AF risk. Sixteen SNPs were genotyped in 113 patients with AF-ESKD-HD and in 157 controls: without AF (NAF) and with ESKD-HD. The distribution of the risk alleles was compared in both groups and between different sub-phenotypes. The multilocus genetic risk score (GRS) was calculated to estimate the cumulative risk conferred by all SNPs. Several loci showed a trend toward an association with permanent AF (perm-AF): CAV1, Cx40 and PITX2. However, GRS was significantly higher in the AF and perm-AF groups, as compared to NAF. Three of the tested variables were independently associated with AF: male sex, history of myocardial infarction (MI) and GRS. The GRS, which combined 13 previously described SNPs, showed a significant and independent association with AF in a Polish population of patients with ESKD-HD and concomitant AF. Further studies on larger groups of patients are needed to confirm the associations.
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Saracyn et al. (2018) conducted a case-control in Atrial fibrillation in end-stage kidney disease (n=270). Multilocus genetic risk score (13 SNPs) vs. Controls without atrial fibrillation was evaluated on Association of genetic risk score with atrial fibrillation (OR 1.24, 95% CI 1.07-1.43, p=0.005). A multilocus genetic risk score combining 13 SNPs was significantly and independently associated with atrial fibrillation in hemodialyzed patients with end-stage kidney disease (OR 1.24 per 0.1-unit increase).
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