Key result
Langevin dynamics and time-dependent Monte Carlo simulations reproduced the observed trend in stall force and force/velocity profile of myosin-V.
The study demonstrates that the powerstroke in myosin-V is a result of the complete free-energy landscape rather than the primary driving force of energy conversion.
No immediate clinical implications; extends biophysical models of myosin-V but leaves human cardiac translation open.
Significance The free-energy landscape of the complete mechanochemical cycle of myosin-V is used in simulating the real-time features of the directional motion. The combination of Langevin dynamics simulations and time-dependent Monte Carlo simulations reproduces the observed trend in terms of stall force and force/velocity profile. The present study also addresses the role of the powerstroke and finds it to be the result of the complete free-energy landscape rather than the driving force of the energy conversion by the system.
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Mukherjee et al. (2017) studied Mechanochemical cycle of myosin-V. Langevin dynamics and time-dependent Monte Carlo simulations was evaluated on Stall force and force/velocity profile. Langevin dynamics and time-dependent Monte Carlo simulations reproduced the observed trend in stall force and force/velocity profile of myosin-V.
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