Key points are not available for this paper at this time.
The global incidence of acute and chronic wounds, combined with mounting antibiotic resistance, expensive hospitalisation, and drug side effects, emphasizes the pressing necessity of cheap, effective, and safe wound care protocols. Under these aspects, polysaccharide films incorporating natural substances have emerged as a greatly promising group of bioactive materials that not only offer physical shielding but also therapeutic activities. Owing to their biodegradability, low cytotoxicity, and superior film-forming potential, polysaccharides with incorporation of natural materials represent ideal candidates for the formulation of new advanced wound dressings. In this review, a thorough and visionary review on natural materials encapsulated polysaccharide-derived films in the treatment of chronic wounds is outlined. It first elaborates on the physiological basis of wound healing, then provides a meticulous overview of the physicochemical and biological properties of major natural materials and polysaccharides responsible for their efficacy as wound dressings. Special emphasis is placed on the introduction of bioactive molecules, such as antimicrobial agents, antioxidants, and growth factors into polysaccharide matrices, transforming them into multi-functional platforms for improved healing and infection prevention. By integrating natural bioactive materials science with clinical needs, this review highlights the revolutionary promise of polysaccharide films loading natural materials in developing next-generation and bio-responsive wound care systems.
Ly et al. (Mon,) studied this question.