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The aim is to investigate how miR863-3p modulates immune responses in plants during bacterial infection.

April 25, 2016Nature CommunicationsOpen Access

miRNA863-3p sequentially targets negative immune regulator ARLPKs and positive regulator SERRATE upon bacterial infection

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The aim is to investigate how miR863-3p modulates immune responses in plants during bacterial infection.
Analyzed the role of miR863-3p in targeting ARLPK1, ARLPK2, and SERRATE during infection by Pseudomonas syringae.
Assessed the effects of miR863-3p on immunity through mRNA degradation and translational inhibition.
MiR863-3p silences ARLPK1 and ARLPK2 to enhance immune responses during early infection.
Later, miR863-3p targets SERRATE, reducing its levels and thereby establishing a negative feedback loop in defense regulation.

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Randomized trial examines miR863-3p's dual role in regulating immunity during bacterial infection, suggesting a novel feedback mechanism.

Niu et al. (2016) studied this question.

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