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studies indicate that nanoparticle-based formulations markedly enhance the bioavailability of citrus bioactives. Specifically, phytosomal formulations of hesperidin and hesperetin have been shown to increase peak serum concentrations (Cmax) following oral administration, whereas nanoemulsion systems facilitate improved solubilization and intestinal transport of lipophilic compounds via micelle formation. By synthesizing recent findings from pharmacological, nutritional, and food science research, this review illuminates pathways for optimizing the health benefits of citrus-derived chemicals. We also discuss the implications for future research and the potential applications of these delivery systems in personalized medicine and nutraceuticals, advocating for a paradigm shift in the development and consumption of citrus products to maximize their health benefits.
Davodabadi et al. (Thu,) studied this question.