Metabolic Profiling of a Mediterranean-Inspired (Poly)phenol-Rich Mixture in the Brain: Perfusion Effect and In Vitro Blood–Brain Barrier Transport Validation

using human brain microvascular endothelial cells (HBMECs), showing improved transport when tested as mixtures. These findings confirm that circulating phenolic metabolites from Mediterranean foods can reach brain tissues, contributing to preventing neurodegenerative diseases.