Key result
Voltage-gated sodium channel β1/β1B subunits play critical roles in cardiac myocyte physiology, and variants in the SCN1B gene are linked to inherited cardiac arrhythmias and epilepsy syndromes.
Nav-β1/β1B subunits play a critical role in cardiac electrophysiology, and SCN1B variants predispose patients to both neurological and cardiac conduction diseases, highlighting the potential need for cardiovascular evaluation in epileptic encephalopathy patients.
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Supports cardiac evaluation in SCN1B epilepsy; leaves open prospective validation of arrhythmia risk and screening.
Edokobi et al. (2018) conducted a review in Cardiac arrhythmias and epilepsy. SCN1B variants (Nav-β1/β1B subunits) was evaluated. Voltage-gated sodium channel β1/β1B subunits play critical roles in cardiac myocyte physiology, and variants in the SCN1B gene are linked to inherited cardiac arrhythmias and epilepsy syndromes.
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