Key result
Restricting the extracellular space by approaching HEK cells to a non-conducting obstacle modulated cardiac sodium current, increasing peak INa near the activation threshold (P=0.0156).
p-value: p=0.0156
Clustering of sodium channels in the intercalated disc potentiates ephaptic interactions, facilitating cardiac impulse transmission when gap junctional coupling is reduced.
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No immediate clinical implications; extends ephaptic models by showing Na channel clustering modulates INa when gap junctions decline.
Hichri et al. (2017) studied this question. Restricting the extracellular space vs. Unrestricted space / baseline was evaluated on Peak INa at step potentials (p=0.0156). Restricting the extracellular space by approaching HEK cells to a non-conducting obstacle modulated cardiac sodium current, increasing peak INa near the activation threshold (P=0.0156).
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