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November 23, 2025The Journal of PhysiologyOpen Access

Electrodiffusion in cardiac intercalated disc nanostructures alters cell–cell action potential transmission via ephaptic coupling: A model study

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Authors

EIEna IvanovicMVMarina VannucciNMNicolae Moise

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Overview

Model study demonstrates ephaptic coupling enhances action potential propagation in cardiomyocytes, suggesting its significance in cardiac conduction.

Key Points

  • Ephaptic coupling involves negative extracellular potentials in narrow intercalated disc clefts that assist action potential propagation.
  • A new finite element model elucidates cell–cell action potential transmission in cardiomyocytes under varying Na + conditions.
  • Simulations reveal that Na + channel clusters and extracellular cleft dynamics significantly influence cardiac conduction mechanisms.
  • Findings underline the structural importance of intercalated discs in regulating action potential transmission via ephaptic interactions.

Cite This Study

Ivanovic et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ddc0ce034ddc34e7d9https://doi.org/10.1113/jp290031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrodiffusion in cardiac intercalated disc nanostructures alters cell–cell action potential transmission via ephaptic coupling: A model study2025
  2. 2Localization of Na<sup>+</sup> channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study2021 · 43 citations
  3. 3Intercalated disk nanoscale structure regulates cardiac conduction2021 · 56 citations
  4. 4Intercalated Disk Nanoscale Structure Regulates Cardiac Conduction2021 · 3 citations
  5. 5Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc2017 · 69 citations