Key result
Finite element modeling demonstrated that intercalated disk nanoscale structural heterogeneity regulates cardiac conduction by desynchronizing the activation of post-junctional Na+ currents.
Why the study?
The structure of the intercalated disk and intercellular cleft is poorly characterized, and no models had incorporated the influence of intercalated disk structure on cardiac conduction.
Population
Finite element model meshes based on transmission electron microscopy images
Comparison
Novel cardiac tissue model incorporating intercalated disk structure vs prior formulations neglecting or simplifying it
Design
Computational finite element modeling and simulation study
Authors
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Challenges passive intercalated disk model; leaves open whether nanoscale targeting modulates conduction or arrhythmias in humans.
Computational modeling demonstrates that the nanoscale structure of the intercalated disk plays an active and significant role in regulating cardiac conduction.
Moise et al. (2021) studied this question. Intercalated disk nanoscale structure modeling vs. Prior modeling formulations that neglect or simplify ID structure was evaluated on Cardiac conduction and cleft polarization. Finite element modeling demonstrated that intercalated disk nanoscale structural heterogeneity regulates cardiac conduction by desynchronizing the activation of post-junctional Na+ currents.
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