Key result
Tetrodotoxin block of cardiac sodium channels in rabbit Purkinje fibers exhibits use-dependent kinetic behavior, indicating that toxin binding and channel gating are not independent.
Population
Rabbit Purkinje fibers
Design
Preclinical
Authors
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Hypothesis-generating for cardiac-specific Na channel pharmacology; leaves open human translation and arrhythmia relevance.
TTX block of cardiac sodium channels exhibits use-dependent kinetics and interacts with channel gating, unlike in nerve cells.
Cohen et al. (1981) studied Cardiac sodium channel function. Tetrodotoxin (TTX) was evaluated on Sodium current (INa) block and kinetics. Tetrodotoxin block of cardiac sodium channels in rabbit Purkinje fibers exhibits use-dependent kinetic behavior, indicating that toxin binding and channel gating are not independent.
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