Key result
Bipolar disorder and schizophrenia were associated with a 2- to 3-fold increased overall mortality and an 11 to 20 years shorter life expectancy compared to the general population.
Why the study?
Do patients with bipolar disorder or schizophrenia have increased mortality from circulatory diseases and reduced life expectancy?
Population
Patients with bipolar disorder or schizophrenia in Denmark, Sweden, and Finland
Design
Cohort
Authors
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May warrant enhanced CV risk monitoring in severe mental illness; extends Nordic mortality data but leaves causal mechanisms and interventions open.
Cohort (n=105,463)
Yes
Do patients with bipolar disorder or schizophrenia have increased mortality from circulatory diseases and reduced life expectancy?
Effect estimate: 11 to 20 years shorter life expectancy
Patients with severe psychiatric disorders in Nordic countries experience significantly higher cardiovascular mortality and a drastically reduced life expectancy of 11 to 20 years.
Laursen et al. (2013) conducted a cohort in Bipolar disorder or schizophrenia (n=105,463). Bipolar disorder or schizophrenia vs. General population was evaluated on Standardized mortality rates (SMRs) for diseases of the circulatory system and overall life expectancy (11 to 20 years shorter life expectancy). Bipolar disorder and schizophrenia were associated with a 2- to 3-fold increased overall mortality and an 11 to 20 years shorter life expectancy compared to the general population.
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