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A 50-year-old woman with a progressive neurologic illness clinically resembling amyotrophic lateral sclerosis had Pick's disease verified at autopsy. This case represents another example of Pick's disease in which the early manifestations were not those of dementia. This patient also showed some unusual histopathologic features, including degeneration of the substantia nigra and occasional "compound Pick bodies."
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Sam et al. (1991) studied this question.
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