Pick's disease and Alzheimer's disease are well-defined, if rare, groups of cases which have been differentiated from the main bulk of the dementing psychoses occurring at and around the presenile period. Although these two sub-groups have much in common on the clinical side, their histopathological features are so strikingly different that many authorities consider them to be separate disease-entities.
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Frank Thorpe (1932) studied this question.
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