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March 20, 1958The Journal of General PhysiologyOpen Access

Pulses of repolarizing current displace membrane potential more than depolarizing current and can initiate sustained repolarization that propagates throughout the fiber.

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Population

Single fibers of ventricular muscle

Comparison

Pulses of repolarizing current applied during… vs Pulses of depolarizing current

Design

Preclinical

Authors

PCPaul F. CranefieldBHBrian F. Hoffman

Discussion

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Overview

Should not alter clinical practice; hypothesis-generating for repolarization dynamics in ventricular myocardium.

Structured PICO

P
Population
Single fibers of ventricular muscle
I
Intervention
Pulses of repolarizing current applied during the plateau of the action potential
C
Comparator
Pulses of depolarizing current
O
Outcome
Displacement of membrane potential and initiation of sustained repolarizationsurrogate

Demonstrates that repolarizing current can initiate sustained, propagated repolarization in ventricular muscle fibers, particularly when extracellular calcium is reduced.

Cite This Study

Cranefield et al. (1958) studied this question.

synapsesocial.com/papers/6a236b1b6bc3bf64e44c92d2https://doi.org/10.1085/jgp.41.4.633
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