Key result
Plastomitin greatly suppressed the 26% increase in the rate of short-lived reactive oxygen species generation induced by doxorubicin in rat heart tissue homogenates.
Why the study?
To investigate the protective effects of the mitochondrial-targeted antioxidant plastomitin against reactive oxygen species hypergeneration induced by doxorubicin.
Does plastomitin reduce doxorubicin-induced reactive oxygen species generation in rat heart homogenates?
Does plastomitin reduce doxorubicin-induced reactive oxygen species generation in rat heart homogenates?
Plastomitin suppresses doxorubicin-induced reactive oxygen species generation in rat heart tissue, suggesting a potential protective role against oxidative stress.
The aim of the present study was to investigate the protective effects of a mitochondrial-targeted antioxidant such as plastomitin through ROS hypergeneration in animals. The average rate of the generation of highly reactive oxygen radicals during oxidative stress, induced by doxorubicin injection in rats and a protective impact of plastomitin use were investigated. The experiments were carried out with rat heart tissue homogenates using EPR spectroscopy. It was found that in case of doxorubicin injection in rats, there is a significant 26% increase in the rate of short-lived reactive oxygen species generation in the homogenate but when doxorubicin and plastomitin were used in combination, this effect was greatly suppressed.
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Timoshin et al. (2023) studied Doxorubicin-induced oxidative stress. Plastomitin vs. Doxorubicin alone was evaluated on Rate of short-lived reactive oxygen species generation. Plastomitin greatly suppressed the 26% increase in the rate of short-lived reactive oxygen species generation induced by doxorubicin in rat heart tissue homogenates.
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