Key result
Endomyocardial biopsy reveals active myocardial inflammation with degenerative cardiomyocyte changes in ARVC.
Why the study?
Recent reports have shown a high frequency of signs of myocardial inflammation in patients with confirmed ARVC.
Case Report (n=1)
No
This case highlights the potential overlap between arrhythmogenic right ventricular cardiomyopathy and inflammatory cardiomyopathies, suggesting that myocardial inflammation may be involved in disease pathogenesis.
Myocardial inflammation may occur in ARVC; this single case leaves open its pathogenic role and any therapeutic implications.
Recent years have been marked by a number of published reports that have shown a high frequency of signs of myocardial inflammation in patients with confirmed arrhythmogenic right ventricular cardiomyopathy (ARVC). This article presents a clinical case of typical phenotypic manifestations of ARVC associated with morphometric signs of subacute myocarditis. A 66-year-old man presented to the emergency department with signs of arrhythmogenic shock caused by ventricular tachycardia. Examination detected electrocardiographic signs of (ARVC), visualized signs of right ventricular dilatation, increased trabeculation, and wall fibrosis. Endomyocardial biopsy of the right ventricular wall showed degenerative alterations of cardiomyocytes with perivascular lymphocytic infiltration and areas of granulation tissue. New facts that evidence inflammatory alterations of the myocardium will still require specifying and reconsidering positions of expert consensuses on diagnostics and treatment of ARVC.
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Бобров et al. (2023) conducted a case report in Arrhythmogenic right ventricular cardiomyopathy (ARVC) with myocardial inflammation (n=1). Myocardial inflammation was evaluated on Phenotypic and morphometric characterization of ARVC and myocarditis. Myocardial inflammation was evident on endomyocardial biopsy, which showed degenerative alterations of cardiomyocytes with perivascular lymphocytic infiltration in a patient with ARVC.
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