Key result
Myocardial inflammatory infiltrates in ARVC were associated with severe structural changes, occurring in 50% of cases with biventricular involvement versus 7.69% of cases with sole RV involvement.
Why the study?
Are inflammatory infiltrates associated with severe structural heart alterations in postmortem ARVC samples?
Population
44 postmortem human heart samples (36 Arrhythmogenic Right Ventricular Cardiomyopathy [ARVC] and 8 controls)
Design
Cross-sectional
Authors
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Postmortem association warrants no practice change; leaves open inflammation's causal role in ARVC severity.
Observational (n=44)
Are inflammatory infiltrates associated with severe structural heart alterations in postmortem ARVC samples?
Absolute Event Rate: 50% vs 7.69%
Inflammatory infiltrates in the ventricular myocardium of ARVC patients are associated with more severe structural heart changes, suggesting inflammation may modulate disease severity.
Campuzano et al. (2012) conducted an observational in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (n=44). Severe ARVC structural alterations (biventricular involvement) vs. Sole right ventricular involvement was evaluated on Presence of inflammatory infiltrates. Myocardial inflammatory infiltrates in ARVC were associated with severe structural changes, occurring in 50% of cases with biventricular involvement versus 7.69% of cases with sole RV involvement.
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