Key result
Treating thyroid storm suppresses refractory VT and improves biventricular heart failure in ARVC.
Case Report (n=1)
No
Hyperthyroidism should be considered as a potential trigger for refractory arrhythmia and biventricular heart failure in patients with ARVC.
May support thyroid evaluation in ARVC with refractory VT; hypothesis-generating and leaves open need for prospective confirmation.
A 48-year-old man who was diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) due to a plakophilin 2 gene mutation developed acute both-sided heart failure with rapid atrial fibrillation and was hospitalized. After admission, sustained ventricular tachycardia, which was refractory to antiarrhythmic agents, occurred repeatedly, and required electrical cardioversion. He was diagnosed with thyroid storm due to Graves' disease, and treatment for hyperthyroidism was initiated. After the treatment, lethal arrhythmia did not reoccur, and biventricular heart failure ameliorated. To our best knowledge, this is the first report in English of a patient with ARVC showing refractory arrhythmia induced by thyroid storm due to Graves' disease.
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Matsubara et al. (2022) conducted a case report in Arrhythmogenic right ventricular cardiomyopathy (ARVC) with thyroid storm due to Graves' disease (n=1). Treatment for hyperthyroidism (hydrocortisone, methimazole, potassium iodide) was evaluated on Resolution of lethal arrhythmia and improvement of heart failure. Treatment for hyperthyroidism effectively suppressed refractory ventricular tachycardia and ameliorated biventricular heart failure in a patient with arrhythmogenic right ventricular cardiomyopathy complicated by thyroid storm.
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