Key result
Male sex was associated with a higher prevalence of carotid atherosclerosis compared to women (55.4% vs 45.8%) and softer plaque morphology, with the morphological difference increasing with age (P=0.005).
Why the study?
What are the age and sex differences in the prevalence and morphology of carotid atherosclerosis?
Population
6,420 adults (3,016 men and 3,404 women) aged 25 to 84 years participating in a population health survey.
Design
Cross-sectional
Authors
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Sex differences in carotid plaque should not yet change screening; leaves open whether morphology predicts events by age and sex.
Cross-Sectional (n=6,420)
What are the age and sex differences in the prevalence and morphology of carotid atherosclerosis?
Absolute Event Rate: 55.4% vs 45.8%
Carotid atherosclerosis prevalence and plaque softness differ significantly by sex and age, with men having softer plaques and a linear increase in prevalence, while women show a curvilinear trend inflecting around menopause.
Joakimsen et al. (1999) conducted a cross-sectional in Carotid atherosclerosis (n=6,420). Male sex vs. Female sex was evaluated on Prevalence of carotid atherosclerosis. Male sex was associated with a higher prevalence of carotid atherosclerosis compared to women (55.4% vs 45.8%) and softer plaque morphology, with the morphological difference increasing with age (P=0.005).
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