BBR@PLGA@PLT nanoparticles significantly improved cardiac function, reduced cardiac collagen deposition, and promoted angiogenesis by resolving inflammation in a rat model of myocardial infarction.
Does intravenous administration of BBR@PLGA@PLT NPs improve cardiac repair and function in a rat model of myocardial infarction?
Platelet membrane-coated PLGA nanoparticles delivering berberin targeted infarcted myocardium, resolved inflammation via macrophage polarization, and improved cardiac function in a rat MI model.
p-value: p=<0.05
Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed.
Zhu et al. (Sat,) conducted a other in Myocardial infarction. BBR@PLGA@PLT NPs vs. Saline or BBR@PLGA NPs was evaluated on Cardiac function (LVEF, FS, LVIDd, LVIDs, EDV, ESV) (p=<0.05). BBR@PLGA@PLT nanoparticles significantly improved cardiac function, reduced cardiac collagen deposition, and promoted angiogenesis by resolving inflammation in a rat model of myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: