December 23, 2005AJP Heart and Circulatory Physiology

C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling

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Why the study?

Does C-phycocyanin improve recovery of heart function and reduce infarct size in an isolated rat heart model of ischemia-reperfusion injury?

Population

Isolated perfused Langendorff rat heart model subjected to 30 min of global ischemia at 37 degrees C…

Comparison

C-phycocyanin or Spirulina preparation perfused… vs Untreated (control) hearts

Design

Preclinical

Follow-up

45 minutes of reperfusion

Authors

MKMahmood KhanMayo Clinic SVSaradhadevi VaradharajThe Ohio State University Wexner Medical Center LGLatha P. GanesanThe Ohio State University

Discussion

Member takes

Implication

Should not change practice; hypothesis-generating for C-phycocyanin cardioprotection in ischemia-reperfusion injury.

Structured PICO

Does C-phycocyanin improve recovery of heart function and reduce infarct size in an isolated rat heart model of ischemia-reperfusion injury?

Population

Isolated perfused Langendorff rat heart model subjected to 30 min of global ischemia at 37 degrees C followed by 45 min of reperfusion

Intervention

C-phycocyanin (10 microM) or Spirulina preparation (50 mg/l) perfused for 15 min before the onset of ischemia and throughout reperfusion

Comparator

Untreated (control) hearts

Outcome

Recovery of heart function (coronary flow, left ventricular developed pressure, rate-pressure product), infarct size, myocardial injury markers (lactate dehydrogenase and creatine kinase), free radical generation, and apoptotic markerssurrogate

C-phycocyanin attenuates ischemia-reperfusion-induced cardiac dysfunction and apoptosis in a rat model, suggesting potential cardioprotective properties mediated through p38 MAPK and ERK1/2 signaling.

Cite This Study

Khan et al. (2005) studied this question.

synapsesocial.com/papers/6a237915003b3cd7fea5d8ae https://doi.org/10.1152/ajpheart.01072.2005

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C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider