Key result
Hydrochlorothiazide improves cardiac function and mitigates fibrosis in heart failure rats via p38MAPK/JNK inhibition.
Why the study?
The impact of thiazide diuretics on cardiac remodeling and prognosis in heart failure remains uncertain.
Does hydrochlorothiazide improve cardiac function and remodeling in a rat model of heart failure?
Population
Rat model of heart failure and H9c2 cell cultures
Comparison
Hydrochlorothiazide (12.5 mg/kg, ig, Qd) vs unstated comparator
Design
Animal and in vitro laboratory study
Follow-up
6 weeks
Authors
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Should not change heart failure practice; hypothesis-generating for p38MAPK/JNK modulation in animal models.
Does hydrochlorothiazide improve cardiac function and remodeling in a rat model of heart failure?
Hydrochlorothiazide improves cardiac function and mitigates fibrosis in a rat model of heart failure by reducing oxidative stress via CAII and NHE1 inhibition.
Luo et al. (2024) studied Heart failure. Hydrochlorothiazide was evaluated on Cardiac function and remodeling. Hydrochlorothiazide enhanced cardiac function and mitigated cardiac fibrosis remodeling in rats with heart failure by reducing oxidative stress and inhibiting the p38MAPK/JNK signaling pathway.
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