Why the study?
Does low-dose hydrochlorothiazide improve serum cystatin C, serum creatinine, and prognosis in patients with asymptomatic chronic heart failure?
Population
66 patients with asymptomatic chronic heart failure
Comparison
Low-dose hydrochlorothiazide added to routine… vs Routine treatment alone
Design
Cohort
Follow-up
6 months
Authors
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May support low-dose diuretic addition in asymptomatic HF; hypothesis-generating for CysC/Scr effects and needs RCT confirmation.
Does low-dose hydrochlorothiazide improve serum cystatin C, serum creatinine, and prognosis in patients with asymptomatic chronic heart failure?
Low-dose hydrochlorothiazide added to routine therapy may improve cardiac and renal biomarkers and prognosis in asymptomatic chronic heart failure without increasing adverse effects.
Zhang et al. (2015) studied this question.
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