Key result
Chronic intermittent myocardial ischemia activates the intrinsic regenerative potential of dormant cardiac stem cells, which stain positive for CD117 and localize near myocardial collagenous scars.
Why the study?
Stem cell therapy could be a promising therapeutic option in ischemic cardiac diseases alongside drug treatment, reperfusion, and surgical revascularization.
Population
A small group of cases who died of cardiac arrhythmia secondary to scarring myocardial infarctions
Design
Autopsy tissue study
Authors
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Should not yet change ischemic heart disease management; hypothesis-generating for CD117+ stem cell activation in regeneration.
Observational (n=5)
No
Cardiac stem cells are present in old myocardial infarctions and can be activated by hypoxic ischemia, suggesting a potential endogenous mechanism for cardiac regeneration.
Ceauşu et al. (2020) conducted an observational in Cardiac arrhythmia secondary to scarring myocardial infarctions (n=5). Chronic intermittent cardiac ischemia (post-myocardial infarction) was evaluated on Presence and activation of cardiac stem cells (CSCs) assessed by immunohistochemistry. Chronic intermittent myocardial ischemia activates the intrinsic regenerative potential of dormant cardiac stem cells, which stain positive for CD117 and localize near myocardial collagenous scars.
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