Key result
Low self-rated health linked to ~38% higher all-cause mortality in diabetes.
Why the study?
Is low self-rated health associated with increased mortality in individuals with diabetes mellitus?
Cohort (n=3,257)
Yes
Is low self-rated health associated with increased mortality in individuals with diabetes mellitus?
Hazard Ratio: 1.38 (95% CI 1.1–1.73)
Self-rated health provides an independent, low-cost prognostic marker for all-cause mortality in patients with diabetes, suggesting its utility in routine clinical practice.
May aid mortality risk assessment in diabetes; hypothesis-generating and should not yet alter practice.
OBJECTIVES: To investigate whether low self-rated health (SRH) is associated with increased mortality in individuals with diabetes. DESIGN: Population-based prospective cohort study. SETTING: Enrolment took place between 1992 and 2000 in four centres (Bilthoven, Heidelberg, Potsdam, Umeå) in a subcohort nested in the European Prospective Investigation into Cancer and Nutrition. PARTICIPANTS: 3257 individuals (mean ± SD age was 55.8±7.6 years and 42% women) with confirmed diagnosis of diabetes mellitus. PRIMARY OUTCOME MEASURE: The authors used Cox proportional hazards modelling to estimate HRs for total mortality controlling for age, centre, sex, educational level, body mass index, physical inactivity, smoking, insulin treatment, hypertension, hyperlipidaemia and history of myocardial infarction, stroke or cancer. RESULTS: During follow-up (mean follow-up ± SD was 8.6±2.3 years), 344 deaths (241 men/103 women) occurred. In a multivariate model, individuals with low SRH were at higher risk of mortality (HR 1.38, 95% CI 1.10 to 1.73) than those with high SRH. The association was mainly driven by increased 5-year mortality and was stronger among individuals with body mass index of <25 kg/m(2) than among obese individuals. In sex-specific analyses, the association was statistically significant in men only. There was no indication of heterogeneity across centres. CONCLUSIONS: Low SRH was associated with increased mortality in individuals with diabetes after controlling for established risk factors. In patients with diabetes with low SRH, the physician should consider a more detailed consultation and intensified support.
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Wennberg et al. (2012) conducted a cohort in Diabetes Mellitus (n=3,257). Low self-rated health vs. High self-rated health was evaluated on Total mortality (HR 1.38, 95% CI 1.10 to 1.73). Low self-rated health was associated with a 38% higher risk of all-cause mortality (HR 1.38, 95% CI 1.10 to 1.73) compared to high self-rated health in individuals with diabetes.
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