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This review provides a comprehensive overview of recent advancements in the generation of reactive oxygen species (ROS) for catalysis and biotherapeutic applications using crystalline porous materials, including metal–organic frameworks (MOFs), covalent organic frameworks (COFs), porous organic cages (POCs), metal–organic cages (MOCs), hydrogen-bonded organic frameworks (HOFs), and molecular sieves. To start with, this review introduces the ideal catalysts for ROS generation and discusses the advantages of crystalline porous materials in this field. Subsequently, strategies for ROS generation, particularly within crystalline porous materials, are outlined. Furthermore, this review delves into the application of ROS in catalysis, highlighting the roles of various types of ROS in chemical transformations. Additionally, we show the application of ROS in biotherapeutics, emphasizing their potential as biotherapeutic agents for targeted therapy. Finally, the challenges and opportunities associated with the development of ROS generation and their applications using crystalline porous materials are briefly discussed. • An overview of progress in crystalline porous materials for ROS generation & applications. • Strategies and mechanisms for ROS generation. • Application of ROS in catalysis based on crystalline porous materials. • Application of ROS in biotherapeutics within crystalline porous materials. Reactive oxygen species (ROS), which are traditionally recognized for their ability to damage biological molecules, have recently emerged as potential catalysts and agents in biotherapeutic applications due to their distinctive chemical properties and biological effects. Crystalline porous materials have garnered considerable attention in ROS generation and applications, thanks to their well-defined structures, large surface areas, and highly customizable properties, offering promising avenues for precise control of ROS production and subsequent release. In this review, we begin by detailing the advantages of crystalline porous materials in ROS manipulation. Subsequently, we introduce the mechanisms of ROS generation, particularly within crystalline porous materials. We then showcase the utilization of ROS in catalysis by crystalline porous materials, emphasizing the roles of different ROS types in facilitating efficient and selective reactions. Additionally, the application of ROS biotherapeutics, particularly in targeted therapy, based on various strategies for ROS generation, has been summarized. Finally, the remaining challenges and prospects for further advancing crystalline porous materials in the realm of ROS-related research and development are discussed.
Qian et al. (Wed,) studied this question.