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June 19, 2025JACC AdvancesOpen Access

Global Trends in Ischemic Heart Disease-Related Mortality From 2000 to 2019

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Why the study?

Ischemic heart disease remains a leading cause of global morbidity and mortality, with persistent disparities based on sex and geographic region.

Population

IHD mortality data from 105 countries from the WHO Mortality Database

Comparison

Trends stratified by sex and geographic region

Design

Observational study using joinpoint regression analysis

Key result

Between 2000 and 2019, global age-standardized mortality for ischemic heart disease declined from 104 to 65.5 per 100,000 individuals (AAPC -2.16; 95% CI -2.13 to -2.20).

Authors

VJVikash JaiswalJEJef Van den EyndeYMYusra Mashkoor

Discussion

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Overview

Global IHD mortality decline may reflect prevention gains; extends observational trends but leaves open regional disparity drivers.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

P
Population
Global ischemic heart disease mortality data from 105 countries spanning 2000 to 2019, analyzed to determine trends and disparities by sex and geographic region.
O
Outcome
Crude mortality rates (CMRs) and age-standardized mortality rates (ASMRs) per 100,000 individualshard clinical

Main Result

Effect estimate: AAPC -2.16 (95% CI -2.13 to -2.20)

Absolute Event Rate: 65.5% vs 104%

While global IHD mortality declined significantly between 2000 and 2019, regional disparities persist, notably with increasing mortality trends in Africa.

Cite This Study

Jaiswal et al. (2025) conducted an observational in Ischemic heart disease. Time period (2000 to 2019) vs. Year 2000 was evaluated on Age-standardized mortality rate (ASMR) per 100,000 individuals (AAPC -2.16, 95% CI -2.13 to -2.20). Between 2000 and 2019, global age-standardized mortality for ischemic heart disease declined from 104 to 65.5 per 100,000 individuals (AAPC -2.16; 95% CI -2.13 to -2.20).

synapsesocial.com/papers/6a2386ad0f6fe640299ed963https://doi.org/10.1016/j.jacadv.2025.101904
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