Key result
Oxidative stress and locally produced angiotensin II play significant roles in the pathogenesis of myocardial repair and ventricular remodelling following myocardial infarction.
Design
Review
Authors
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May inform post-MI cardioprotective strategies targeting these pathways; leaves open validation in prospective trials.
Understanding the cellular and molecular mechanisms of extracellular matrix accumulation, including oxidative stress and local angiotensin II, is essential for designing cardioprotective strategies post-MI.
Yao Sun (2008) conducted a review in Myocardial infarction and heart failure. Oxidative stress and locally produced angiotensin II was evaluated. Oxidative stress and locally produced angiotensin II play significant roles in the pathogenesis of myocardial repair and ventricular remodelling following myocardial infarction.
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