Key result
Vitamin D3 supplementation for 3 months significantly increased time domain parameters of heart rate variability in male patients with vitamin D3 deficient Asthma COPD overlap syndrome.
Why the study?
Vitamin D3 deficiency is common in Asthma COPD overlap syndrome, and vitamin D3 administration increases heart rate variability in healthy subjects.
Does vitamin D3 supplementation improve heart rate variability in male patients with vitamin D3 deficient Asthma COPD overlap syndrome?
RCT (n=51)
randomized
Does vitamin D3 supplementation improve heart rate variability in male patients with vitamin D3 deficient Asthma COPD overlap syndrome?
Vitamin D3 supplementation significantly improves heart rate variability in male patients with vitamin D3 deficient Asthma COPD overlap syndrome.
May support vitamin D3 repletion for autonomic function in deficient male ACO patients; provides RCT evidence extending HRV benefits to this group.
Background:Vitamin D3 deficiency is common in Asthma COPD overlap syndrome (ACO) and administration of vitamin D3 increased heart rate variability in healthy subjects. Objective: This randomized clinical trial aimed to investigate the therapeutic effect of vitamin D3administration on time domain measures of heart rate variability in 51 male vitamin D3(<30- 10ng/ml) deficient ACO patients. Methods: Patients were given either vitaminD3 capsule or placebo per week orally for 3 months and serum vitamin D3 level and time domain parameters of heart rate variability were assessed before and after the intervention. For statistical analysis, independent and paired sample t test was used. Results: Before intervention, vitamin D3 level and time domain parameters of heart rate variability were similar in all patients but these outcome measures significantly increased in vitamin D3 treated but not in placebo treated patients after 3 months. Conclusion:In conclusion, vitaminD3therapy is effective to improve heart rate variability in vitamin D3 deficient Asthma COPD overlap syndrome. J Bangladesh Soc Physiol. 2020, December; 15(2): 98-107
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Nahar et al. (2020) conducted an RCT in Asthma COPD overlap syndrome (ACO) (n=51). Vitamin D3 vs. Placebo was evaluated on Time domain parameters of heart rate variability. Vitamin D3 supplementation for 3 months significantly increased time domain parameters of heart rate variability in male patients with vitamin D3 deficient Asthma COPD overlap syndrome.
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