Key result
In patients with non-ischemic dilated cardiomyopathy, calcitriol levels were significantly lower in those with abnormal turbulence slope compared to those with normal turbulence slope (16.6 vs 29.4 pg/mL).
Why the study?
Are decreased vitamin D levels associated with impaired cardiac autonomic functions in patients with chronic heart failure?
Cross-Sectional (n=96)
No
Are decreased vitamin D levels associated with impaired cardiac autonomic functions in patients with chronic heart failure?
Absolute Event Rate: 16.6% vs 29.4%
p-value: p=0.018
Vitamin D insufficiency is associated with impaired cardiac autonomic functions, as evidenced by reduced heart rate variability and abnormal heart rate turbulence, in patients with non-ischemic dilated cardiomyopathy.
Vitamin D levels may associate with HRV/HRT in dilated cardiomyopathy HF; leaves open any causal or therapeutic role.
OBJECTIVE: Vitamin D status has been implicated in the pathophysiology of heart failure (HF). The aim of this study was to investigate the association between vitamin D levels with heart rate variability and heart rate turbulence in patients with heart failure whom had ischemic and non-ischemic dilated cardiomyopathy. METHODS: Study designed as an observational cross-sectional study. Seventy-one patients [36 non-ischemic dilated cardiomyopathy (NIDCM), 35 ischemic dilated cardiomyopathy (IDCM)] with chronic heart failure and 25 control subject were included. It was evaluated the association between 25 hydroxyvitamin D [25(OH)D] and calcitriol levels with heart rate variability time domain (SDNN, SDANN, RMSSD) and heart rate turbulence [turbulence onset (TO), turbulence slope (TS)] parameters. Statistical analysis was performed using Kruskal-Wallis test and ANOVA. RESULTS: Calcitriol levels in NIDCM patients with abnormal TO and TS were significantly lower than NIDCM patients with normal TO (17.1 ± 11.3 vs. 27.6 ± 15.5 pg/mL, p=0.05) and TS (16.6 ± 9.1 vs. 29.4 ± 16.9 pg/mL, p=.018). There was a positive correlation between 25 (OH) D with heart rate variability parameters SDNN (r=0.368, p=0.027) and SDANN (r=0.360, p=0.031). It was not found any association between vitamin D and parameters of heart rate variability and heart rate turbulence in IDCM patients. CONCLUSION: Insufficiency of vitamin D may have deleterious effects on cardiac autonomic functions which were showed with heart rate turbulence and heart rate variability in patients with NIDCM. Vitamin D levels might be a predictor to determine the sudden cardiac death in patients with non-ischemic etiology.
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Çetįn et al. (2014) conducted a cross-sectional in Chronic heart failure (ischemic and non-ischemic dilated cardiomyopathy) (n=96). Vitamin D levels (25(OH)D and calcitriol) vs. Normal vitamin D levels / Healthy controls was evaluated on Calcitriol levels in NIDCM patients with abnormal versus normal turbulence slope (TS) (p=0.018). In patients with non-ischemic dilated cardiomyopathy, calcitriol levels were significantly lower in those with abnormal turbulence slope compared to those with normal turbulence slope (16.6 vs 29.4 pg/mL).
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