Key result
Vitamin D replacement in individuals with Vitamin D deficiency significantly improved cardiac autonomic function, increasing SDNN from 68.58 ms to 119.87 ms (p<0.001).
Why the study?
Although vitamin D deficiency is known to be associated with cardiac autonomic dysfunction, there are no convincing data on the effect of vitamin D replacement.
Does Vitamin D replacement improve cardiac autonomic function assessed by HRV in apparently healthy individuals with Vitamin D deficiency?
Observational (n=102)
Does Vitamin D replacement improve cardiac autonomic function assessed by HRV in apparently healthy individuals with Vitamin D deficiency?
Absolute Event Rate: 119.87% vs 68.58%
p-value: p=<0.001
Vitamin D replacement in apparently healthy individuals with Vitamin D deficiency significantly improves cardiac autonomic function as measured by heart rate variability.
Vitamin D repletion should not yet change practice; hypothesis-generating for autonomic benefits and requires randomized confirmation.
BACKGROUND: Vitamin D (VitD) has important prohormone functions in a wide range of clinical processes. Although it is known that individuals with VitD deficiency have cardiac autonomic dysfunction, there are no convincing data regarding the effect of VitD replacement. We aimed to evaluate the impact of VitD replacement on cardiac autonomic dysfunction. METHODS: Fifty-two apparently healthy subjects with VitD deficiency and 50 healthy control subjects were enrolled. Prior to VitD replacement, 24-hr Holter recordings were obtained, and HRV parameters were recorded. VitD levels were measured 2 months later after replacement, and control 24-hr Holter recordings were analyzed. RESULTS: The mean age of the patients was 36.04 ± 7.6 years, and 53.9% were female. SDNN (68.58 ± 13.53 vs. 121.02 ± 27.45 ms, p = .001), SDANN (95.96 ± 22.26 vs. 166.48 ± 32.97 ms, p = .001), RMSSD (23 vs. 59 ms, p < .001), and PNN50 (6.5% vs. 36%, p < .001) were significantly lower in patients with VitD deficiency compared with the control group. HRV parameters were improved after VitD replacement [SDNN (68.58 ± 13.53 to 119.87 ± 28.28 ms, p < .001), SDANN (95.96 ± 22.26 to 164.44 ± 33.90 ms, p < .001), RMSSD (23 to 58 ms, p < .001), and PNN50 (6.5 to 33%, p < .001)]. CONCLUSION: The present study suggested that VitD deficiency was significantly correlated with impaired cardiac autonomic functions assessed by parameters of HRV, and cardiac autonomic dysfunction improved after VitD replacement in otherwise apparently healthy individuals.
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Doğduş et al. (2019) conducted an observational in Vitamin D deficiency (n=102). Vitamin D replacement vs. Baseline (pre-replacement) was evaluated on SDNN (ms) (p=<0.001). Vitamin D replacement in individuals with Vitamin D deficiency significantly improved cardiac autonomic function, increasing SDNN from 68.58 ms to 119.87 ms (p<0.001).
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