Key result
Vitamin D <20 ng/ml is linked to worse systolic but better diastolic function in HFrEF.
Why the study?
The association between serum vitamin D levels and cardiac systolic and diastolic functions in patients with LV systolic heart failure is widely debated.
Does serum vitamin D level correlate with echocardiographic parameters of systolic and diastolic function in patients with HFrEF?
Population
60 patients with symptomatic heart failure and systolic dysfunction (EF <40%)
Comparison
Serum 25-hydroxy vitamin D level <20 ng/ml vs ≥20 ng/ml
Design
Cross-sectional study
Authors
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Vitamin D levels may correlate with systolic/diastolic function in HFrEF; leaves open whether supplementation improves outcomes.
Cross-Sectional (n=60)
No
Does serum vitamin D level correlate with echocardiographic parameters of systolic and diastolic function in patients with HFrEF?
Vitamin D levels appear to have a biphasic effect on cardiac function in HFrEF patients, with lower levels (<20 ng/ml) associated with worse systolic but better diastolic echocardiographic parameters.
Rahman et al. (2015) conducted a cross-sectional in LV systolic heart failure (n=60). Serum 25-hydroxy vitamin D level <20 ng/ml vs. Serum 25-hydroxy vitamin D level ⩾20 ng/ml was evaluated on Cardiac systolic and diastolic function parameters. Vitamin D levels <20 ng/ml were associated with worse systolic function (higher end systolic volume, p=0.05) but better diastolic function compared to levels ⩾20 ng/ml in systolic heart failure.
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