Key result
Lower 25-hydroxyvitamin D levels (per 10 ng/mL decrease) were associated with an increased rate of cardiovascular hospitalizations (HR 1.74; 95% CI 1.08-2.80; P=0.023).
Why the study?
Vitamin D deficiency is prevalent in heart failure, but its relevance in early stages of HFpEF was unknown.
Does lower 25-hydroxyvitamin D serum level predict mortality and cardiovascular hospitalizations in patients with diastolic dysfunction or HFpEF?
Population
787 outpatients with risk factors for DD or history of HF from the DIAST-CHF study
Comparison
25(OH)D serum levels
Design
Cohort study
Follow-up
Up to 5 years
Authors
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May aid HFpEF risk stratification; hypothesis-generating and should not change practice without randomized trials.
Cohort (n=787)
Does lower 25-hydroxyvitamin D serum level predict mortality and cardiovascular hospitalizations in patients with diastolic dysfunction or HFpEF?
Hazard Ratio: 1.74 (95% CI 1.08–2.8)
p-value: p=0.023
In patients with diastolic dysfunction or HFpEF, lower serum vitamin D levels are associated with worse functional capacity and independently predict an increased risk of cardiovascular hospitalizations.
Nolte et al. (2019) conducted a cohort in Diastolic dysfunction or heart failure with preserved ejection fraction (HFpEF) (n=787). Lower 25(OH)D levels vs. Higher 25(OH)D levels was evaluated on Cardiovascular hospitalizations (HR 1.74, 95% CI 1.08-2.80, p=0.023). Lower 25-hydroxyvitamin D levels (per 10 ng/mL decrease) were associated with an increased rate of cardiovascular hospitalizations (HR 1.74; 95% CI 1.08-2.80; P=0.023).
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