Key result
Reduced vitamin D (<20 ng/ml) was associated with worse systolic and diastolic echocardiographic parameters in patients with systolic heart failure compared to levels ≥20 ng/ml.
Why the study?
The association between vitamin D and heart failure, especially left ventricular function, remains unclear.
Are reduced vitamin D levels (<20 ng/ml) associated with worse echocardiographic parameters of systolic and diastolic function in patients with systolic heart failure?
Cross-Sectional (n=90)
No
Are reduced vitamin D levels (<20 ng/ml) associated with worse echocardiographic parameters of systolic and diastolic function in patients with systolic heart failure?
Reduced vitamin D levels (<20 ng/ml) are associated with worse echocardiographic parameters of systolic and diastolic function in patients with systolic heart failure.
Does not support changing vitamin D management in systolic heart failure; leaves open whether supplementation improves echocardiographic parameters.
Background: The association between vitamin D and heart failure, especially left ventricular (LV) function, is still not clear. Objectives: We aimed to study the correlation between 25-hydroxy vitamin D levels and parameters of cardiac systolic and diastolic functions in patients with LV systolic heart failure. Materials and Methods: Ninety patients of heart failure coming to our hospital with systolic heart failure (LV ejection fraction <40%) were included. Venous sample were taken for measurement of 25-hyrdoxy vitamin D levels. Transthoracic echocardiography was done for all patients, and parameters of LV systolic and diastolic functions were taken. Results: Compared to patients having vitamin D <20 ng/ml, patients having vitamin D levels ≥20 ng/ml had higher early diastolic mitral annular velocity (e') , significantly lower ratio of early diastolic mitral inflow velocity (E) to e' (E/e') , significantly shorter isovolumetric relaxation time (IVRT) suggestive of better diastolic function. Furthermore, patients having vitamin D <20 ng/ml had higher LV end-systolic volume, LV end-systolic diameter, larger LV end-diastolic diameter, higher interventricular septum thickness, higher LV wall thickness, and higher LV mass. Conclusion: Reduced vitamin D (<20 ng/ml) was associated with worse systolic function in terms of systolic volume and diameter, diastolic function in terms of lower e′ , higher E/e′ , and longer IVRT.
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Mohanty et al. (2021) conducted a cross-sectional in systolic heart failure (n=90). Reduced vitamin D (<20 ng/ml) vs. Vitamin D ≥20 ng/ml was evaluated on Echocardiographic parameters of LV systolic and diastolic functions. Reduced vitamin D (<20 ng/ml) was associated with worse systolic and diastolic echocardiographic parameters in patients with systolic heart failure compared to levels ≥20 ng/ml.
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