Key result
Vitamin D supplementation did not significantly improve left ventricular ejection fraction (MD 0.74, 95% CI -0.29 to 1.76) or other cardiac function parameters in patients with heart failure.
Why the study?
The study was conducted to systematically evaluate the effects of vitamin D supplementation in heart failure patients.
Does vitamin D supplementation improve cardiac function in patients with heart failure?
Meta-Analysis (n=1,099)
Does vitamin D supplementation improve cardiac function in patients with heart failure?
Mean Difference: 0.74 (95% CI -0.29–1.76)
p-value: p=0.16
Vitamin D supplementation does not significantly improve cardiac structure or function in patients with heart failure.
Vitamin D supplementation yields no LVEF, LVEDD, or BNP benefit in HF; challenges earlier positive reports and discourages routine supplementation.
Background: Systematic evaluation of the effects of vitamin D supplementation in heart failure (HF) patients. Methods: Searches were conducted on National Library of Medicine, Web of Science, Cochrane Library, Google Scholar, China National Knowledge Infrastructure, and WANFANG databases. We analyzed data by using Review Manager 5.4 software. All are from the earliest records to March 2023. Outcome indicators analyzed the left ventricular ejection fraction (LVEF), the left ventricular end-diastolic internal diameter (LVEDD), the B-type brain natriuretic peptide (BNP) level and the 25-hydroxy vitamin D (25(OH)D) level. Results: Ten studies with 1099 patients were included. LVEF (mean difference (MD) = 0.74, 95% CI: –0.29 to 1.76, p = 0.41), LVEDD (MD = –0.59, 95% CI: –1.83 to 0.66, p = 0.25), BNP (MD = –0.08, 95% CI: –0.24 to 0.08, p = 0.34), 25(OH)D (MD = 0.41, 95% CI: –0.28 to 1.11, p = 0.25) are not statistically significant. And there is no heterogeneity in the results of LVEF, LVEDD and BNP indicators. Conclusions: Vitamin D supplementation may not be helpful in the clinical management of patients with HF.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2023) conducted a meta-analysis in Heart failure (n=1,099). Vitamin D supplementation vs. Placebo or no drug was evaluated on Left ventricular ejection fraction (LVEF) (MD 0.74, 95% CI -0.29 to 1.76, p=0.16). Vitamin D supplementation did not significantly improve left ventricular ejection fraction (MD 0.74, 95% CI -0.29 to 1.76) or other cardiac function parameters in patients with heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: