Key result
Vitamin D supplementation fails to reduce mortality or improve cardiac function in CHF.
Why the study?
Vitamin D is a crucial modulator of cardiovascular illness including heart failure, but its association with severity and complications of congestive heart failure remains unclear.
Does vitamin D supplementation improve ventricular remodeling, cardiac function, and quality of life in patients with congestive heart failure?
Systematic Review (n=6,509)
Does vitamin D supplementation improve ventricular remodeling, cardiac function, and quality of life in patients with congestive heart failure?
Vitamin D supplementation may offer cardioprotective effects in congestive heart failure by improving ventricular remodeling, cardiac function, and quality of life.
Low vitamin D levels associate with worse HF outcomes and biomarkers; leaves open whether supplementation improves prognosis.
Many studies have shown that vitamin D is a crucial modulator of hypertension and cardiovascular illness, including heart failure. Heart failure (HF) is still the leading cause of mortality worldwide. Patients with heart failure who have low vitamin D levels experience worse outcomes, which associate with known clinical correlations and biomarkers. Additionally, patients with low vitamin D levels are more likely to have diabetes, hypertension, atherosclerosis, and other precursor conditions to heart failure. There are some hints in recent experimental research on how vitamin D can have cardioprotective effects. Vitamin D supplementation might improve ventricular remodeling in heart failure patients, however, this is still unclear. It aims to evaluate the association between vitamin D and congestive heart failure (CHF). This systematic review used research from the previous ten years (January 2012-2022) retrieved from the following databases: PubMed/PMC (PubMed Central)/Medline and Cochrane Library. Using the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020 guidelines, removing duplicates, screening of title and abstract, application of eligibility criteria, and quality appraisal, 13 articles were retained for systemic review. There were 10 randomized controlled trials and three observational studies. Vitamin D supplementation lowers serum inflammatory marker levels and improves the quality of life in CHF patients. Vitamin D treatment inhibits ventricular remodeling and improves cardiac function in a patient with CHF.
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Hazique et al. (2022) conducted a systematic review in Congestive heart failure (n=6,509). Vitamin D supplementation vs. Placebo or standard care was evaluated on Cardiac function, mortality, and quality of life. Vitamin D supplementation has a weak and ambiguous impact on ventricular remodeling and cardiac function in patients with congestive heart failure, and does not lower cardiac mortality or increase exercise tolerance.
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