Key result
High-dose vitamin D linked to lower NT-proBNP and improved LVEF in deficient heart failure.
Observational (n=97)
No
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Shows high-dose vitamin D improves cardiac function and remodeling in deficient heart failure patients, suggesting structural benefits despite unchanged quality of life.
Introduction: Heart Failure is a leading cause of mortality worldwide including India. Most cross sectional studies have demonstrated heart failure is associated with deficiency of essential micronutrients including Vitamin D which may play a important role in pathogenesis of ventricular remodelling in heart failure. Aim: Our study performed aimed to determine the effect of supplementation in patients of Heart Failure presenting with Vitamin D deficiency to our institute on severity of Heart Failure. Design and Method: 97 patients of Heart failure coming to our institute were given conventional therapies for Heart Failure along with Vitamin supplementation based on serum Vitamin D levels and followed up for 3 months. Results: Patient of Heart failure having Vitamin D deficiency had significant reduction in cardiac biomarkers (NT-pro BNP levels), improvement in Left ventricular ejection fraction (LVEF) and more favourable reverse remodelling determined by Left ventricular end diastolic and systolic diameter (LVEDD & LVESD) though quality of life determined by WHODAS 2.0 score did not changed following 12 weeks supplementation of High Dose Vitamin D. Conclusion: Recognising and treatment of Vitamin D deficiency may determine long term prognosis in patients of Heart Failure.
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Mohanty et al. (2022) conducted an observational in Congestive heart failure with vitamin D deficiency (n=97). High-dose vitamin D supplementation alongside conventional heart failure therapy was evaluated on NT-proBNP levels, LVEF, left ventricular remodeling (LVEDD & LVESD), and quality of life (WHODAS 2.0 score). High-dose vitamin D supplementation for 12 weeks in 97 vitamin D-deficient heart failure patients significantly reduced NT-proBNP and improved LVEF and LV remodeling, without changing WHODAS 2.0 QoL.
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