Key result
Noradrenaline and ATP produce vasodilatation in the rabbit coronary artery by a direct action on the smooth muscle.
This preclinical study demonstrates that sympathetic co-transmitters noradrenaline and ATP directly induce vasodilation in coronary smooth muscle independent of the endothelium.
No takes yet. Share an insight, caveat, or question.
Findings limited to rabbit models should not alter clinical coronary vasomotor management; leaves open direct transmitter effects for translational research.
Corr et al. (1991) studied this question. Noradrenaline (NA), adenosine, and adenosine 5'-triphosphate (ATP) was evaluated on Vasodilator and vasoconstrictor responses. Noradrenaline and ATP produce vasodilatation in the rabbit coronary artery by a direct action on the smooth muscle.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: