The Pattern of Thrombosis in Patients with JAK2 V617F Mutation

Background: JAK2V617F mutation is recurrent in MPN and reported as a marker for occult MPN in patients with splanchnic vein thrombosis. Objective: To better estimate the pattern of arterial and venous thrombosis in a Lebanese series in order to define the potential risk and to evaluate the current treatment. Methods: Ninety-five consecutive patients were included and all arterial and venous thrombotic events were documented, altogether with the clinical and demographic data. Results: Twenty-eight % of patients developed arterial thrombosis and 29% venous thrombosis with PV predilection for DVT and BCS. 27% and 5% of patients had thrombosis at presentation or history of thrombosis. However; subsequent thrombosis may develop in 20% of cases and may be the cause of death in 12.6%. Two cases with family aggregation were observed. Conclusion: Close surveillance should be carried out in JAK2V617F-mutated patients with special attention to subsequent thrombosis development. Familial clustering should be looked for.